Cohorts
The CMC faculty has initiated and runs, or contributed to, or has full access various cohorts of patients and healthy controls. This wealth of exclusive data is an essential prerequisite for replication of novel, exploratory findings. A selection is listed below:
COMPLETED STUDIES
| Study name | n | Available Data |
|---|---|---|
| NATIONAL STUDIES | ||
| * FOR2107 | >2,800 | adults with SZ/BD/MDD, high risk, HC. MRT, GWAS, blood, microbiome, deep phenotyping, clinical, 2 and 5 yrs follow up |
| NaKo (National Cohort) | 40.000 | Adults with neurological and psychiatric diseases“, age 20-69; test of fluid intelligence |
| * ENCERT | 255 | adults with somatoform disorders; 4 year follow-up |
| * ASD-Net | >2000 | children, adults with ASD, age range 1-72, all IQ ranges, behavioural data |
| * BIPOLIFE | 2.214 | adults with BD, high risk (incl. DEP, ADHD), clinical, emotional-cognitive therapy (n=305), MRT (n=512), (epi-)genetics |
| TALIS (Video-Study for Germany) | pupils:1,140 teachers: 50 |
pupils, age 12-19; process information about maths in school + success in learning |
| WiKo (evaluation of „welcome-classes“ in Berlin) | headmasters, teachers: 371 |
classwork implementation and success in newly immigrated pupils |
| * Panic-Net I | 369 | panic disorder/agoraphobia; clinical, Behavioral Avoidance Test (n=364), MRT (n=89), (epi-)genetics, CBT (369), 6 months follow up |
| * Panic-Net II | 165 | panic disorder/agoraphobia; clinical, behavioral, MRT (n=69), (epi-)genetics, CBT (n=165), 6 months follow up |
| * PROTECT-AD | 726 | ANX; clinical, behavioral, MRT (n=330), (epi-)genetics, CBT. 6 months follow up |
| SOPHO-Net (Social Phobia Psychotherapy Network) | 495 | social phobia pat., age 18–70; clinical data, treatment CBT / psychodynamic therapy |
| RELEASE (PTSD after Childhood Abuse in Adults Network) | 193 | PTSD adult pat., age 18-65, clinical data, two different CBT treatments |
| * D-CPT (PTSD after Childhood Abuse in Adolescents´ Network) | 88 | PTSD adolescent pat., age 14-21, clinical data, CBT vs. WL |
| INTERNATIONAL STUDIES | ||
| ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis): multiple subgroups | BD: >3,500 MDD: >5,000 SZ: >2,900 HC: >51.000 |
adults; MRT, clinical data |
| IMAGEN | 2000 | European adolescents age 14 + parents; 2/4/6/ yr follow ups; MRT, genetics, clinical, cognitive + behavioral assessments |
| PGC (Psychiatric Genomics Consortium) | > 400.000 | meta- and mega-analyses of genome-wide data in ADHD, Alzheimer’s disease, ASD, BD, eating disorders, MDD, OCD/Tourette syndrome, PTSD, SZ, substance use, ANX |
| PsyScan | ~700 | SZ/SZA adults, ultra-high risk subjects; MRT, DTI, clinical, cognitive, genetics, longitudinal |
| Children’s Worlds | >100,000 | children age 8-14; material, social, cultural circumstances of upbringing, and education / cognition |
* indicates these studies are led by CMC faculty
There are other German cohorts that the CMC faculty has access to on request, e.g. the 1000 Brains (MRI, n=941 adults), GEDA (n=24,016 adults), KiGGS (n=15,023 children/ adolescents), SHIP (n=4,308 adults, MRI, GWAS), and many other local and international samples.